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目的探讨乙型肝炎患者前S1(Pre—S1)抗原与HBV标志物之间的相关性及临床意义。方法用ELISA法对431例乙型肝炎患者及60例健康体检者检测Pre-S1和HBsAg、HBsAb、HBeAb、HBcAb,并对其结果进行回顾性分析。结果各种模式乙型肝炎均与健康对照组比较,(P<0.01)结果均有非常显著性意义;乙肝各项阳性指标与Pre-S1检测结果显示HBeAg阳性Pre-S1最高。结论Pre-S1是HBV感染和复制的标志,比HBeAg反映HBV复制更敏感,是HBV存在和复制较为直接的标志,对乙肝血清标志物检测起重要补充作用,对临床判断HBV复制和疾病的预后有重要参考价值。
Objective To investigate the correlation between pre-S1 antigen and HBV markers in patients with hepatitis B and its clinical significance. Methods Pre-S1, HBsAg, HBsAb, HBeAb and HBcAb were detected in 431 hepatitis B patients and 60 healthy subjects by ELISA. The results were retrospectively analyzed. Results Hepatitis B was significantly different from that of healthy controls (P <0.01). The positive rates of HBsAg and Pre-S1 in HBsAg-positive Pre-S1 were the highest among all the patterns. Conclusion Pre-S1 is a marker of HBV infection and replication, which is more sensitive than HBeAg to reflect HBV replication. It is a direct marker of HBV existence and replication. Pre-S1 plays an important role in the detection of hepatitis B serum markers. It is of great value in clinical judgment of HBV replication and disease prognosis Have important reference value.