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家兔镉中毒后肾脏可出现淀粉样沉着并形成淀粉样蛋白,同时尿中可出现β_2-微球蛋白。有人认为该两种蛋白都是组织相容性抗原(HLA)的轻链。本文探讨了肾中淀粉样沉着与尿β_2-微球蛋白增加的关系。方法:将含镉0、3、10、30、100ppm的饲料分别喂给5只猴,共153周。杀后取一定量的脏器加入5倍量的0.2M Sucrose(内加
Kidney cadmium poisoning occurs amyloidosis and amyloid formation in the kidneys, while β_2-microglobulin may appear in the urine. It is thought that both proteins are light chains of histocompatibility antigens (HLA). This article explored the relationship between amyloid deposition in the kidney and increased urinary β 2 -microglobulin. Methods: 0, 3, 10, 30 and 100ppm cadmium were fed to 5 monkeys respectively for 153 weeks. After killing a certain amount of organs to join 5 times the amount of 0.2M Sucrose (plus