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目的探究分析β-七叶皂甙钠及丹参联合应用治疗胶质瘤术后患者脑水肿的临床疗效。方法选取我院自2011年1月至2014年12月期间收治的胶质瘤患者58例随机分两组,每组各29例,试验组患者在常规甘露醇脱水治疗的基础上加β-七叶皂甙钠及丹参治疗;对照组患者在常规甘露醇脱水治疗的基础上加用β-七叶皂甙钠。对比分析两组患者在一个治疗周期后颅内压及水肿直径变化情况,综合比较两组患者的治疗总有效率。结果试验组患者治疗显效率为62.07%,以及治疗总有效率为96.55%,均明显高于对照组(58.62%、72.41%),P<0.05,具有显著性。且其一个治疗周期后颅内压及水肿直径缓解情况明显优于对照组患者,P<0.05,差异具有显著性。结论β-七叶皂甙钠及丹参联合应用治疗胶质瘤术后患者脑水肿的临床疗效明显优于单纯β-七叶皂甙钠疗法,患者用药后水肿直径明显减小,颅内压缓解优势明显,治疗总有效率高,有一定的推广价值和临床使用意义。
Objective To investigate the clinical efficacy of β-aescinate combined with salvia miltiorrhiza in the treatment of cerebral edema in patients with glioma. Methods Fifty-eight patients with glioma admitted to our hospital from January 2011 to December 2014 were randomly divided into two groups (n = 29 in each group). Patients in the test group were given β-heptakis Sodium aescinate and Salvia treatment; control group patients in the conventional mannitol dehydration therapy based on the use of β-aescinate sodium. The changes of intracranial pressure and edema diameter of the two groups after a treatment cycle were compared and analyzed. The total effective rate of the two groups was compared. Results The effective rate of treatment in experimental group was 62.07%, and the total effective rate of treatment was 96.55%, which were significantly higher than that in control group (58.62%, 72.41%), P <0.05. And one of the treatment cycles after intracranial pressure and edema diameter relief was significantly better than the control group, P <0.05, the difference was significant. Conclusion The combination of β-aescinate and salvia miltiorrhiza in the treatment of glioma postoperative brain edema clinical efficacy was significantly better than the simple β-aescinate sodium therapy, patients with medication edema diameter was significantly reduced, the advantage of intracranial pressure relief obvious , The total effective rate of treatment, there are some promotional value and clinical significance.