目的　探讨血压变异性与高血压性肾脏损害的关系。方法　对 5 2例高血压病患者及2 0例健康对照者均进行 2 4h动态血压监测 (ABPM) ,以各时间段每 30min血压均值的标准差 (s)作为血压变异性的指标 ,同期观察尿 β2 微球蛋白 ( β2 MG)的含量。结果　高血压病组患者血压变异性各项参数值与正常对照组比较均有明显增高 (P <0 .0 5或P <0 .0 1)。 2 4h收缩压变异性、白昼收缩压变异性与尿 β2 MG含量均呈显著正相关 (P <0 .0 0 1)。结论　高血压病患者血压变异性明显高于正常血压者 ;血压变异性与高血压性肾脏损害密切相关 Objective To investigate the relationship between variability of blood pressure and hypertensive kidney damage. Methods 52 cases of hypertensive patients and 20 healthy controls were all monitored for 24 hours ambulatory blood pressure monitoring (ABPM). The standard deviation (s) of blood pressure every 30 minutes was taken as the index of blood pressure variability during the same period Urine β2 microglobulin (β2 MG) content. Results The parameters of blood pressure variability in hypertensive patients were significantly higher than those in normal controls (P <0.05 or P <0.01). 24 h systolic blood pressure variability, daytime systolic blood pressure variability and urine β2 MG content were significantly correlated (P <0. 001). Conclusion The variability of hypertension in patients with hypertension is significantly higher than that of normal blood pressure; variability of hypertension is closely related to hypertensive renal damage