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难治性癫痫(intractable epilepsy)即一般意义上的药物性难治性癫痫(medically intractable epilepsy),在癫痫中约占20％～30％。长期以来,如何阐明难治性癫痫的产生机制,提高对难治性癫痫的控制率一直是癫痫研究的热点。近年,由于受到肿瘤多药耐药(multiple drug resistance,MDR)研究的启示,MDR在难治性癫痫中所扮演的角色逐渐被认识,其中P糖蛋白(P-glycopmtein,PgP)与难治性癫痫的关系研究相对较为深入,本文就此作一综述。 1 Pgp的特性与MDR的关系 Pgp是一分子量为170 kD的膜结合蛋白,转运蛋白ATP结合物(ATP-binding cassette transporters,ABCT)超家族的成员之一,由MDR1基因编码。人类MDR基因分为MDR1和MDR2两种,其中MDR1基因产物Pgp与多药耐药的产生关系非常密切。正常情况下,哺乳动物各种组织均
The intractable epilepsy is a medically intractable epilepsy in the general sense, accounting for about 20% to 30% of epilepsy. For a long time, how to elucidate the mechanism of refractory epilepsy and improve the control rate of refractory epilepsy has always been the focus of epilepsy research. In recent years, the role of MDR in refractory epilepsy has been gradually recognized due to its implications for the study of multiple drug resistance (MDR), in which P-glycoprotein (PgP) and refractory The relationship between epilepsy research is relatively more in-depth, this article gives a review. Relationship between Pgp and MDR Pgp is a 170 kD membrane-bound protein, a member of the ATP-binding cassette transporters (ABCT) superfamily, encoded by the MDR1 gene. Human MDR genes are divided into two kinds of MDR1 and MDR2, MDR1 gene product Pgp and multi-drug resistance are closely related. Under normal circumstances, mammalian tissues are all