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目的探讨血清N-末端脑钠肽前体(NT-proBNP)用于急性冠脉综合征(ACS)的临床诊断价值。方法分别收集三组入院冠心病患者血清,包括28例稳定型心绞痛、33例不稳定型心绞痛、31例急性心肌梗死,以98例健康体检血清作为对照,检测各组血清的NT-proBNP和肌钙蛋白I(cTnI)水平。结果血清NT-proBNP浓度随患者罹患急性冠脉综合征的严重程度递增,差异具有统计学意义(P<0.05);以ROC曲线对NT-proBNP鉴别ACS的效能进行分析,其线下面积为0.79;对三组患者血清的NT-proBNP与cTnI的水平进行了相关性分析,NT-proBNP与cTnI在检测ACS中成线性相关(r=0.524,P<0.001)。结论 NT-proBNP是一种用于心衰诊断的较好的血清学标志物,可在鉴别患者急性冠脉综合征严重程度方面发挥良好的临床应用价值。
Objective To investigate the value of serum NT-proBNP in the diagnosis of acute coronary syndrome (ACS). Methods Serum samples were collected from three groups of patients with coronary heart disease, including 28 cases of stable angina pectoris, 33 cases of unstable angina pectoris and 31 cases of acute myocardial infarction. The serum of NT-proBNP and muscle Calpain I (cTnI) levels. Results Serum NT-proBNP concentration increased with the severity of acute coronary syndrome (P <0.05). The ROC curve was used to analyze the efficacy of NT-proBNP in identifying ACS. The area under the curve was 0.79 The levels of NT-proBNP and cTnI in sera of three groups were analyzed. NT-proBNP and cTnI were linearly correlated with ACS (r = 0.524, P <0.001). Conclusion NT-proBNP is a good serological marker for the diagnosis of heart failure, which can play a good clinical value in identifying the severity of acute coronary syndrome in patients.