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[目的]探讨趋化因子受体(CXCR4)和血管内皮生长因子(VEGF-C)在食管癌组织中的表达情况,及其在食管癌发生、浸润、转移中的作用。[方法]应用免疫组织化学方法检测82例食管癌组织、20例正常食管组织中CXCR4、VEGF-C表达情况,并分析其与临床病理参数的关系。[结果]CXCR4在82例食管癌组织中的阳性表达率为64.6%,CXCR4表达与食管癌患者年龄、性别无关(P>0.05),而与分化程度、病理类型、TNM分期、浸润深度和淋巴结转移有相关性(P<0.05)。VEGF-C在82例食管癌组织中的阳性表达率为74.4%,VEGF-C表达与食管癌患者年龄、性别、分化程度和病理类型无关(P>0.05),而与TNM分期、浸润深度和淋巴结转移有相关性(P<0.05)。[结论]CXCR4和VEGF-C在食管癌组织中呈高表达,且与食管癌细胞侵袭、转移和淋巴结转移相关,在促进食管癌侵袭和转移中可能存在协同作用。
[Objective] To investigate the expression of chemokine receptor (CXCR4) and vascular endothelial growth factor (VEGF-C) in esophageal carcinoma and its role in the carcinogenesis, invasion and metastasis of esophageal cancer. [Methods] The expressions of CXCR4 and VEGF-C in 82 esophageal cancer tissues and 20 normal esophageal tissues were detected by immunohistochemistry. The relationship between the expression of CXCR4 and VEGF-C was analyzed with clinicopathological parameters. [Results] The positive expression rate of CXCR4 in 82 cases of esophageal cancer tissues was 64.6%. The expression of CXCR4 was not related to the age and sex of esophageal cancer patients (P> 0.05), but with the differentiation degree, pathological type, TNM stage, depth of invasion and lymph nodes Metastasis was correlated (P <0.05). The positive rate of VEGF-C in 82 cases of esophageal cancer was 74.4%. The expression of VEGF-C was not correlated with the age, sex, differentiation and pathological type of esophageal cancer (P> 0.05), but correlated with the TNM stage, depth of invasion Lymph node metastasis was correlated (P <0.05). [Conclusion] CXCR4 and VEGF-C are overexpressed in esophageal cancer tissues, and are associated with invasion, metastasis and lymph node metastasis of esophageal cancer cells, and may play synergistic roles in promoting esophageal cancer invasion and metastasis.