采用酒精灌胃和胃外在体的大鼠动物模型，观察思密达对酒精性胃粘膜损害的保护作用。结果为思密达组胃粘膜损伤明显小于对照组（Ｐ＜０．０５）；肥大细胞脱颗粒也少于对照组（Ｐ＜０．００１）。同时应用激光多普勒流量仪检测胃粘膜血流，显示思密达组鼠胃粘膜基础血流增加（Ｐ＜０．０５），并减轻酒精引起的胃粘膜血流减少（Ｐ＜０．０１）。还发现思密达组胃粘膜上即粘液层与固有腺体表层之间有肥大细胞积聚。结果提示思密达对胃粘膜的保护作用与胃粘膜血流增加，减少肥大细胞脱颗粒有关 Animal models of alcoholic gavage and gastric extraoral body were used to observe the protective effect of Smecta on alcoholic gastric mucosal injury. The results showed that gastric mucosal lesion in Smecta group was significantly less than that in control group (P <0.05); mast cells degranulation was also less than that in control group (P <0.001). At the same time, the blood flow of gastric mucosa was detected by laser Doppler flowmeter, which showed that gastric mucosal basal blood flow increased (P <0.05) and alcohol reduced gastric mucosal blood flow decreased (P <0.01 ). Smectite also found that gastric mucosa that is, between the mucus layer and the surface of the inherent gland mast cell accumulation. The results suggest that the protective effect of Smectite on gastric mucosa and gastric mucosal blood flow increased to reduce mast cell degranulation