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目的探讨血、尿S100B蛋白含量以及尿S100B蛋白/肌酐的比值对新生儿窒息的早期诊断和病情监测的应用价值。方法检测了63例新生儿窒息患者出生后第1、2、3天的血、尿S100B蛋白含量和尿S100B蛋白/肌酐比值,并在1周内对试验组患儿进行分类。结果重度窒息患儿3 d内血、尿S100B蛋白及尿S100B蛋白比值均高于对照组(P<0.05);轻度窒息组患儿第1天血、尿S100B蛋白及尿S100B蛋白比值高于健康对照组(P<0.05),从第2天起与健康对照组比较差异无统计学意义;尿S100B蛋白/肌酐比值比单独检测尿S100B蛋白更稳定、可靠,能提高诊断的灵敏度、特异度。结论血、尿S100B蛋白能客观地反映窒息患儿的病情,对提高缺氧缺血性脑病(HIE)的早期诊断和病情监测具有一定的实用价值。
Objective To investigate the value of serum and urine S100B protein and urine S100B protein / creatinine ratio in early diagnosis and condition monitoring of neonatal asphyxia. Methods Blood, urine S100B protein and urine S100B protein / creatinine ratio were measured in 63 neonates with asphyxia at 1, 2 and 3 days after birth. The patients in the experimental group were classified within 1 week. Results The ratio of S100B protein in blood and urine and the S100B protein in urine of children with severe asphyxia were higher than those in control group (P <0.05) within 3 days. The blood, urine S100B protein and urine S100B protein in children with mild asphyxia were higher than those in control group (P <0.05). There was no significant difference between the control group and the control group on day 2. The ratio of urine S100B protein / creatinine was more stable and reliable than the urine S100B protein alone, which could improve the diagnostic sensitivity and specificity . Conclusion Serum and urine S100B protein can objectively reflect the condition of children with asphyxia, and have certain practical value in improving the early diagnosis and condition monitoring of hypoxic-ischemic encephalopathy (HIE).