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目的观察布地奈德雾化吸入治疗新生儿胎粪吸入综合征的相关临床指标变化。方法将轻度和中度新生儿胎粪吸入综合征20例随机分成观察组(10例)和对照组(10例)。观察组在常规治疗的基础上加用布地奈德雾化吸入;对照组采用常规治疗。观察2组的住院时间、吸氧时间、胸部X线转为清晰时间、呼吸窘迫评分和氧合指数。结果观察组住院时间为(9.24±2.40)d,低于对照组的(12.3±2.8)d,差异有统计学意义(Z=-2.551,P=0.011);观察组吸氧时间(4.7±1.5)d,低于对照组的(6.4±1.6)d,差异有统计学意义(Z=-2.307,P=0.021);观察组X线转为清晰时间为(8.4±2.2)d,低于对照组的(9.8±2.8)d,差异有统计学意义(Z=-2.527,P=0.012)。结论布地奈德雾化吸入治疗新生儿胎粪吸入综合征能缩短住院时间、氧气依赖时间和X线转为清晰时间,未见明显不良反应出现。
Objective To observe the change of relevant clinical indexes of budesonide inhalation for neonatal meconium aspiration syndrome. Methods Twenty patients with mild and moderate neonatal meconium aspiration syndrome were randomly divided into observation group (n = 10) and control group (n = 10). The observation group was treated with budesonide inhalation on the basis of routine treatment, while the control group was treated by conventional therapy. The length of hospital stay, oxygen inhalation time, chest X-ray, clear time, respiratory distress score and oxygenation index were observed. Results The length of hospital stay in the observation group was (9.24 ± 2.40) d, which was lower than that in the control group (12.3 ± 2.8) d, with a significant difference (Z = -2.551, P = 0.011) ) d, lower than the control group (6.4 ± 1.6) d, the difference was statistically significant (Z = -2.307, P = 0.021); the observation group X-ray to clear time (8.4 ± 2.2) d, Group (9.8 ± 2.8) d, the difference was statistically significant (Z = -2.527, P = 0.012). Conclusion Budesonide inhalation for neonatal meconium aspiration inhalation can shorten the length of hospital stay, oxygen-dependent time and X-ray to clear time, no obvious adverse reactions.