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目的探讨DAB2IP和β-连环蛋白(β-catenin)在胃癌组织中的表达及其与临床病理因素的关系,分析DAB2IP和β-catenin蛋白之间的相关性。方法应用免疫组化En Vision法检测70例胃癌组织和20例相应癌旁组织中DAB2IP和β-catenin的表达,并对胃癌患者临床病理资料进行分析。结果 DAB2IP蛋白在胃癌和癌旁组织中的阳性表达率分别为47.14%和90.00%,两者比较差异有统计学意义(P<0.05)。β-catenin蛋白在胃癌组织中的阳性表达率为71.42%,高于癌旁组织的0.00%,差异有统计学意义(P<0.05)。DAB2IP和β-catenin蛋白表达在胃癌患者临床分期、浸润深度及淋巴结是否转移间的差异有统计学意义(P<0.05),而与患者年龄、性别、肿瘤大小及分化程度无关(P>0.05)。胃癌中DAB2IP和β-catenin蛋白表达呈负相关(P<0.05)。结论胃癌组织中DAB2IP表达下调,β-catenin表达升高,且二者表达呈负相关,DAB2IP和β-catenin异常表达与胃癌临床分期、浸润和转移有关。
Objective To investigate the expression of DAB2IP and β-catenin in gastric cancer and its relationship with clinicopathological factors, and to analyze the correlation between DAB2IP and β-catenin. Methods The expression of DAB2IP and β-catenin in 70 cases of gastric carcinoma and 20 cases of corresponding paracancerous tissues was detected by En Vision method. The clinicopathological data of gastric cancer were analyzed. Results The positive rates of DAB2IP protein in gastric cancer and paracancerous tissues were 47.14% and 90.00%, respectively, with statistical significance (P <0.05). The positive rate of β-catenin in gastric cancer tissues was 71.42%, which was higher than that in adjacent tissues (0.00%) (P <0.05). There were significant differences in the clinical stage, depth of invasion and lymph node metastasis between gastric cancer patients and DAB2IP and β-catenin (P <0.05), but not with the age, gender, tumor size and differentiation (P> 0.05) . The expression of DAB2IP and β-catenin in gastric cancer was negatively correlated (P <0.05). Conclusion DAB2IP expression is down-regulated and β-catenin is up-regulated in gastric cancer. The expression of DAB2IP and β-catenin is negatively correlated with clinical stage, invasion and metastasis.