创制一个结构全新的药物并不容易且费时很长,故有时亦从已知的药物入手,通过结构改造或修饰,保持或增强药物的优良特性,去除或减弱不良性质,其有效手段之一为前药(Pro-drug)设计。所谓前药设计系指用化学方法把具有生物活性的原药转变成无活性的衍生物,在体内经酶或非酶解作用释放出原药而发挥药效。这种无活性的衍生物即叫做前药。 Creating an entirely new drug is not easy and takes a long time, so it is sometimes effective to start with known drugs and to modify or modify the structure to maintain or enhance the superior properties of the drug to remove or attenuate the undesirable properties. Pro-drug design. The so-called prodrug design refers to the chemical method of biological activity of the original drug into inactive derivatives, in the body by enzyme or non-enzymatic release of the original drug and play a pharmacodynamic effect. This inactive derivative is called a prodrug.