正常老年人及青年哮喘患者的淋巴细胞显示β-肾上腺素能受体功能障碍,若β-肾上腺素能功能障碍出现于开始衰老的气道,则有助于解释晚期发生哮喘的机理。本文拟比较正常老年及正常青年受试者于标准乙酰甲胆碱激发试验后对沙丁胺醇的反应。对象与方法本次研究包括17名健康青年人(20～36岁)及17名健康老年人(60～76岁)。试验分3次进行:第1d仅吸入乙酰甲胆碱,开始剂量1.5μg,每隔5min剂量累积加倍,于每次剂量前即刻单独测定流量环,终点为50％肺活量时的最大呼气量(FEF5O)下降35％或乙酰甲胆碱最大累积量为 Lymphocytes in normal and young asthmatics show beta-adrenergic receptor dysfunction, and if beta-adrenergic dysfunction occurs in the airways where senescence begins, it helps to explain the mechanism of later asthma. This article intends to compare normal elderly and normal youth subjects with standard methacholine challenge test response to salbutamol. Subjects and Methods The study included 17 healthy young people (20-36 years old) and 17 healthy seniors (60-76 years old). The test was divided into 3 times: only methacholine was inhaled on day 1, and the initial dose was 1.5 μg, doubling the dose every 5 minutes. The flow volume was measured immediately before each dose and the end point was the maximum expiratory volume at 50% FEF5O) decreased by 35% or the maximum cumulative amount of methacholine was