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通过脂肪酸与N-羟乙基苯并异噻唑啉-3-酮反应,制备了9个未见文献报道的脂肪酸2-(苯并异噻唑啉-3-酮-2-基)乙基酯类化合物。所有化合物的结构均经IR、1H NMR、ESI-MS和元素分析确认。选取革兰氏阳性菌[枯草芽孢杆菌(ISM 6513)、金黄色葡萄球菌(ATCC 6538)、白色葡萄球菌(ATCC 12228)]和革兰氏阴性菌[大肠杆菌(ISM 6585)、肺炎克雷伯菌(ATCC 4352)、绿脓杆菌(ATCC 15442)]测试合成化合物的抑菌能力。测试结果表明,化合物对革兰氏阳性菌表现出优良的生长抑制活性,50%生长抑制浓度仅为4mg/L。
Nine non-reported fatty acid 2- (benzisothiazolin-3-one-2-yl) ethyl esters were prepared by the reaction of fatty acids with N-hydroxyethylbenzisothiazolin- Compound. The structures of all compounds were confirmed by IR, 1H NMR, ESI-MS and elemental analysis. Gram-positive bacteria [Bacillus subtilis (ISM 6513), Staphylococcus aureus (ATCC 6538), Staphylococcus aureus (ATCC 12228)] and gram negative bacteria [Escherichia coli (ISM 6585) (ATCC 4352), Pseudomonas aeruginosa (ATCC 15442)] were tested for their ability to inhibit bacteriostasis. The test results showed that the compounds showed good growth inhibitory activity against Gram-positive bacteria, and the 50% growth inhibition concentration was only 4 mg / L.