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目的探讨珠海市手足口病的流行病学特点。方法利用荧光PCR检测手足口病临床诊断标本和健康人群标本柯萨奇病毒A组l6型(coxsackievirus A16,CoxA16)、肠道埃可病毒71型(enterovirus 71,EV71)以及非EV71和CoxA16其他肠道病毒阳性率。采用描述性流行病学研究方法进行流行病学特征分析。结果 319份临床样本EV71、CoxA16以及非EV71和CoxA16其他肠道病毒阳性率分别为26.02%,6.90%和30.09%;180份健康人群样本EV71和CoxA16均阴性,非EV71和CoxA16其他肠道病毒阳性率2.78%。在105份手足口病实验室诊断病例中,男性68例,女性37例。1～5岁感染病例数最多,占实验室诊断病例的86.67%。病例主要集中在3～7月,占诊断总数的85.71%,高峰在6月。病例以散居婴幼儿为主。结论珠海市手足口病临床诊断病例中EV71、CoxA16以及非EV71和CoxA16其他肠道病毒阳性率显著高于健康人群。实验室诊断病例以1～5岁托幼儿童为主,男性多于女性,病例发生有明显的季节性。
Objective To investigate the epidemiological characteristics of hand-foot-mouth disease in Zhuhai. Methods Fluorescent PCR was used to detect Coxsackievirus A16 (CoxA16), enterovirus 71 (EV71) and non-EV71 and CoxA16 other intestinal Road virus positive rate. Descriptive epidemiological methods were used for epidemiological analysis. Results The positive rates of EV71, CoxA16 and other non-EV71 and CoxA16 enterovirus in 319 clinical samples were 26.02%, 6.90% and 30.09%, respectively. The positive samples of EV71 and CoxA16 from 180 healthy people and the positive samples from other non-EV71 and CoxA16 other enteroviruses 2.78% rate. In 105 cases of hand, foot and mouth disease laboratory diagnosed cases, 68 males and 37 females. 1 to 5 years old the largest number of infections, accounting for 86.67% of laboratory diagnosis cases. The cases mainly concentrated in 3 ~ 7 months, accounting for 85.71% of the total number of diagnoses, the peak in June. Cases of scattered infants and young children based. Conclusions The positive rates of EV71, CoxA16, and other enterovirus other than EV71 and CoxA16 in clinically diagnosed HFMD in Zhuhai were significantly higher than those in healthy people. Laboratory diagnosis of cases to 1 to 5-year-old child care-based, more men than women, the case occurred obvious seasonal.