本文报道蛇毒溶栓素(ATE)对家犬、猕猴体内外凝血作用的影响.体外实验表明:ATE具有类凝血酶样作用,能使去钙血浆和纤维蛋白原直接凝固,它不激活Ⅻ因子,产生是非交联的纤维蛋白,并且有纤溶酶样作用,能直接溶解纤维蛋白,产生抗凝作用.体内实验表明:ATE显著延长全血凝固时间、凝血酶时间和凝血酶原时间,注射ATE后血浆中纤维蛋白原降低,优球蛋白溶解时间缩短,三P试验阳性,血小板减少.体内外实验表明,ATE具有去纤、纤溶、抗血小板功能和抗凝效应. In this paper, we report the effect of venom thromotoxin (ATE) on blood coagulation in vivo and in vitro in dogs and macaques.In vitro experiments show that ATE has the thrombin-like effect of direct coagulation of plasma and fibrinogen, , Produce non-cross-linked fibrin, and plasmin-like role, can directly dissolve fibrin, produce anticoagulant effect in vivo experiments show that: ATE significantly extended whole blood clotting time, thrombin time and prothrombin time, injection ATE decreased plasma fibrinogen, euglobulin lysis time shortened, three P test was positive, thrombocytopenia.In vitro and in vivo experiments show that ATE with defibrase, fibrinolysis, anti-platelet function and anticoagulant effect.