论文部分内容阅读
目的:探讨经支气管针吸活检(transbronchial needle aspiration,TBNA)在ⅢA-N2期非小细胞肺癌(non-smallcell lung cancer,NSCLC)新辅助化疗后纵隔再分期中的临床应用价值和安全性。方法:15例经TBNA证实的ⅢA-N2期NSCLC患者给予新辅助化疗后行TBNA再分期,所有患者行肺癌根治切除术及淋巴结清扫术分析TBNA在NSCLC新辅助化疗后纵隔再分期中的诊断敏感性、特异性、准确性、阳性预测值和阴性预测值。结果:TBNA活检的敏感性、特异性、准确性、阳性预测值和阴性预测值分别是80.6%、100%、87.2%、100%和72.7%。病理分型总符合率为80%。术前采用TBNA的c-N分期准确率达86.7%(13/15)。所有患者均未出现严重并发症。结论:经TBNA对NSCLC进行纵隔再分期准确率高,安全性高,具有一定的临床实用价值。
Objective: To investigate the clinical value and safety of transbronchial needle aspiration (TBNA) in mediastinal re-staging after neoadjuvant chemotherapy in stage ⅢA-N2 non-smallcell lung cancer (NSCLC). Methods: Fifteen patients with stage ⅢA-N2 NSCLC confirmed by TBNA underwent neoadjuvant chemotherapy. All patients underwent radical resection of lung cancer and lymphadenectomy to analyze the diagnostic sensitivity of TBNA in mediastinal re-staging after neoadjuvant chemotherapy for NSCLC Sex, specificity, accuracy, positive predictive value and negative predictive value. Results: The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of TBNA biopsy were 80.6%, 100%, 87.2%, 100% and 72.7%, respectively. The total coincidence rate of pathological typing was 80%. Preoperative TBNA c-N staging accuracy rate of 86.7% (13/15). No serious complications occurred in all patients. Conclusion: The high accuracy and safety of mediastinum re-staging of NSCLC by TBNA have certain clinical value.