论文部分内容阅读
目的 :探讨各种原因惊厥患儿血清中烯醇酶 (NSE)的含量变化 ,及常用神经保护剂干预后其含量的变化规律及临床意义。方法 :采集71例惊厥患儿血清标本 ,用ELISA法测定其含量。结果 :惊厥发生后的2天内NSE明显升高 ,随时间的延长 ,浓度逐渐下降 ,第7天时已基本正常。结论 :不同原因惊厥的患儿血清NSE浓度在惊厥后2天内达高峰 ,以新生儿缺氧缺血性脑病(HIE)及急性脑损伤致惊厥增高最明显 ,其他依次为癫痫、各种感染、高热惊厥。NSE随病情恢复和时间的延长 ,其浓度逐渐下降 ,达正常水平的时间与损伤的类型及程度有关 ,以高热惊厥最快 ,HIE恢复最慢 ,多数患儿7天内达正常水平。
Objective: To investigate the changes of serum enolase (NSE) in children with seizures of various causes and the changes and clinical significance of its contents after the intervention of common neuroprotective agents. Methods: Serum samples of 71 children with convulsion were collected and their contents were determined by ELISA. Results: The NSE was significantly increased within 2 days after convulsion and gradually decreased with time. It was almost normal on the 7th day. Conclusion: Serum NSE concentrations in children with different causes of convulsion reached their peak within 2 days after convulsion, with the most obvious increase of convulsion in neonates with hypoxic-ischemic encephalopathy (HIE) and acute brain injury, followed by epilepsy, various infections, Fever convulsions. With the recovery of the disease and the prolongation of time, the concentration of NSE gradually decreased. The time up to the normal level was related to the type and degree of injury. The onset of febrile seizures was fastest and the recovery of HIE was the slowest. Most children reached normal levels within 7 days.