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本实验在6只戊巴比妥纳麻醉狗中,用多道生理记录仪同步记录一系列反映心肌收缩性和舒张性能的动力学指标,综合分析了福寿草总甙对左心功能的影响。福寿草总甙用生理盐水稀释,静脉缓慢推注给药,剂量为0.1mg/kg,10分钟后即见到显著反应。与用药前对比,Vmax、dp/dtmax、-dp/dtmax以及心力环的心力单位分别增加8.3%,6%、18.0%、18.1%(P均<0.05),t-dp/dtmax缩短5%(P<0.05),LVEDP下降31.6%(P<0.05),120分钟后
In this experiment, in a series of 6 pentobarbital anesthetized dogs, a series of physiological recorders were used to simultaneously record a series of kinetic indicators reflecting the myocardial contractility and diastolic performance, and the effects of Fushou Caojing on left cardiac function were comprehensively analyzed. The total alfalfa grass was diluted with normal saline and injected intravenously at a dose of 0.1 mg/kg. A significant response was seen 10 minutes later. Compared with pretreatment, Vmax, dp/dtmax, -dp/dtmax, and heart rate units increased by 8.3%, 6%, 18.0%, and 18.1%, respectively (P <0.05), and t-dp/dtmax decreased by 5%. P<0.05), LVEDP decreased 31.6% (P<0.05) after 120 minutes