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近年来，脉冲电磁场（ PEMFs）在分子、细胞、组织和器官水平对成骨的影响已被广泛研究。PEMFs通过影响细胞分子信号转导、调节相关基因、蛋白合成以及各种细胞因子分泌来调节细胞增殖和分化，抑制骨吸收，促进新骨形成和骨折愈合，并被广泛用于临床上治疗骨折、骨折延迟愈合、骨不连以及脊柱融合。此外，PEMFs还能够提高与组织工程支架联合培养的种子细胞活性。“,”In recent years,pulsed electromagnetic fields(PEMFs) has been studied extensively in osteo-genic effect at the molecular,cellular,tissue and organ levels.Here is to make a review of the effects of PEMFs on bone formation and bone resorption were reviewed.By regulating cellular,molecular signal transduc-tion,related gene expression,protein synthesis and secretion of various cytokines,PEMFs regulate cell prolifera-tion and differentiation,inhibit bone resorption,promote new bone formation and bone fracture healing ,and is widely used in the clinical treatment for bone fractures ,delayed union,nonunion,and spinal fusion.In addition, PEMFs can also improve the activities of seed cells co -cultured with tissue engineering scaffolds .