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目的探讨长期家庭氧疗(LTDOT)对缓解期慢性阻塞性肺疾病(COPD)患者的疗效。方法选取治疗出院的缓解期COPD患者56例,随机分为观察组和对照组,各28例。观察组在常规治疗的基础上给予LTDOT,每日吸氧15 h以上,氧流量1~2 L/min,治疗持续18个月;对照组则未进行家庭氧疗。测定两组患者治疗前后的肺功能中第一秒用力呼气容积占预计值百分比(FEV1%预计值)、血气分析指标动脉血氧分压(Pa O2)和二氧化碳分压(Pa CO2)。采用SPSS 18.0统计软件进行统计分析,计量资料用均数±标准差(xˉ±s)表示,治疗前后比较采用配对t检验,组间比较采用方差分析。计数资料用率(%)表示,采用χ2检验,P<0.05表示差异有统计学意义。结果观察组Pa O2水平、FEV1占预计值均高于对照组,差异有统计学意义(P<0.01)。结论 LTDOT能有效改善缓解期COPD患者的肺功能和Pa O2水平。
Objective To investigate the effect of long-term home oxygen therapy (LTDOT) on patients with chronic obstructive pulmonary disease (COPD) during remission. Methods Fifty-six patients with COPD were randomly divided into observation group and control group, with 28 cases in each group. The observation group was given LTDOT on the basis of routine treatment, daily oxygenation more than 15 h, oxygen flow 1 ~ 2 L / min, the treatment lasted 18 months; the control group did not conduct home oxygen therapy. The percent of predicted first second forced expiratory volume (FEV 1% predicted), PaO 2 and PaCO 2 were measured before and after treatment in both groups. SPSS 18.0 statistical software was used for statistical analysis. The measurement data were expressed as mean ± standard deviation (xˉ ± s), paired t-test before and after treatment, and variance analysis between groups. Counting data with the rate (%) said that using χ2 test, P <0.05 said the difference was statistically significant. Results The level of Pa O2 in the observation group was higher than that of the control group, with a statistically significant difference (P <0.01). Conclusion LTDOT can effectively improve lung function and Pa O2 level in COPD patients during remission.