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目的：探讨胰岛素抵抗是否是妊娠高血压综合征的病因。方法：选取1998年在上海市第一人民医院进行孕中期产前妊娠期糖尿病筛选异常的所有孕妇199例为研究对象，抽取空腹静脉血测定葡萄糖及胰岛素水平并计算胰岛素敏感性指数，并随访孕晚期妊娠高血压综合征发生情况，比较妊娠高血压组(n=39)和正常血压组(n=160)胰岛素敏感性的差异。结果：妊高征组空腹血糖、空腹胰岛素、胰岛素敏感指数较正常血压组明显升高(P＜005)。结论：孕中期胰岛素抵抗是妊娠高血压综合征发生的原因之一。
Objective: To investigate whether insulin resistance is the cause of pregnancy-induced hypertension syndrome. Methods: A total of 199 pregnant women with abnormal screening of prenatal gestational diabetes mellitus in the first trimester of Shanghai First People’s Hospital were selected as the research objects. The fasting venous blood was collected to measure the glucose and insulin levels and the insulin sensitivity index The incidence of late pregnancy-induced hypertension syndrome was compared with that of insulin sensitivity in pregnancy-induced hypertension (n = 39) and normotensive (n = 160). Results: The fasting blood glucose, fasting insulin and insulin sensitivity index in PIH group were significantly higher than those in normotensive group (P <005). Conclusion: The second trimester of insulin resistance is one of the causes of pregnancy induced hypertension syndrome.