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目的:研究食管癌患者免疫功能的变化规律,探索食管癌的免疫发病机制。方法:应用形态学方法测定食管癌患者LBT、RBC-C3bRR、RBC-ICR及NTER;用ELISA法测定食管癌患者血清sIL-2R和TNF-α水平;用生化方法测定食管癌患者血清NO含量,并进行统计学分析。结果:食管癌患者血清NO含量、LBT、RBC-C3bRR和NTER均显著低于正常对照组(P均<0.001);而血清sIL-2R含量、血清TNF-α含量及RBC-ICR均显著高于正常对照组(P均<0.001)。肿瘤根治术后患者血清NO含量、LBT、RBC-C3bRR和NTER较术前明显升高(P<0.05;<0.001;<0.001;<0.05),但仍低于正常对照组(P均<0.001):而血清sIL-2R含量、血清TNF-α含量及RBC-ICR较术前明显降低(P均<0.001),但仍高于正常对照组(P均<0.001)。本实验还发现食管癌患者RBC-C3bRR与血清NO含量及LBT呈正相关,与血清sIL-2R含量呈负相关。结论:食管癌患者的多项免疫指标均发生了明显的改变,多项免疫指标的联合检测对食管癌发病机理探讨、疗效观察和预后判断均有重要的临床意义。
Objective: To study the changes of immune function in patients with esophageal cancer and to explore the immune pathogenesis of esophageal cancer. Methods: The serum levels of sIL-2R and TNF-α in patients with esophageal cancer were determined by ELISA. The serum levels of NO, IL-6 and TNF-α in patients with esophageal cancer were detected by biochemical methods. And statistical analysis. Results: The serum levels of NO, LBT, RBC-C3bRR and NTER in patients with esophageal cancer were significantly lower than those in the normal controls (all P <0.001), while the levels of serum sIL-2R, serum TNF-α and RBC- Normal control group (P <0.001). The serum levels of NO, LBT, RBC-C3bRR and NTER in patients with tumor radical operation were significantly higher than those before operation (P <0.05; <0.001, <0.001, <0.05) Serum sIL-2R, serum TNF-α and RBC-ICR were significantly lower than those before operation (all P <0.001), but still higher than those of the normal control group (all P <0.001). The experiment also found that patients with esophageal cancer RBC-C3bRR and serum NO content and LBT was positively correlated with serum sIL-2R content was negatively correlated. Conclusion: A number of immune indicators of patients with esophageal cancer have undergone significant changes, the combination of a number of immune markers detection of esophageal cancer pathogenesis, efficacy and prognosis have important clinical significance.