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[目的]了解江西省AFP病例监测脊灰疫苗相关株的状况,分析江西省近年人群中脊灰病毒变化趋势。[方法]对江西省2004～2007年分离出脊灰疫苗相关株的AFP病例进行流行病学和病原学分析。[结果](1)Ⅲ型分离率和构成比从2006年开始显著上升,而且,Ⅲ型发生变异最多,变异核甘酸数也最多。(2)疫苗相关株的58例AFP病例中未免疫或未全程免疫的儿童占51.7%。(3)脊灰病毒分离率与采集标本时的服苗时间有关。[结论]对脊灰病毒在人群中的变化趋势进行分析,可以预测VDPVs的发生和流行,可为提前采取防控措施提供依据。消灭脊灰进程中,尽早实现使用脊灰灭活疫苗、直至停止使用脊灰疫苗很有必要。
[Objective] To understand the status of poliovirus-related strains surveillance in AFP cases in Jiangxi Province and analyze the trend of poliovirus in Jiangxi population in recent years. [Method] The epidemic and etiological analysis of AFP cases isolated from poliovirus-associated strains in Jiangxi Province from 2004 to 2007 were conducted. [Result] (1) The separation rate and composition ratio of type Ⅲ increased significantly from 2006, and type Ⅲ had the most variation and the number of variant nucleotides was the most. (2) 51.7% of the 58 non-immunized or non-immunized children in vaccine-related AFP cases. (3) poliovirus isolation rate and collection of specimens when the service-taking time. [Conclusion] The analysis of the change trend of poliovirus in human population can predict the occurrence and prevalence of VDPVs, which may provide the basis for prevention and control measures in advance. Polio eradication process, the early use of polio inactivated vaccine, polo ralph lauren pas cher, it is necessary to stop using polio vaccine.