目的通过动物实验研究次水杨酸铋的止泻作用。方法采用番泻叶致泻法、肠推进炭末排出时间、在体回肠运动和对全肠水分的影响等试验观察受试物的作用。结果次水杨酸铋可以对抗由番泻叶引起的腹泻，减少肠腔内水分的含量，减少肠内容积，但不影响肠蠕动。结论次水杨酸铋具有止泻作用，可防治多种病因引起的腹泻。 Objective To study the anti-diarrhea effect of bismuth sub salicylate by animal experiments. Methods The effect of the test substance was observed by the method of diarrhea induced by senna, the time of excretion of carbon in the intestinal tract, the movement in the body ileum and the water in the whole intestine. Results Bismuth subsalicylate could resist the diarrhea caused by senna, reduce the content of water in the intestine, reduce the volume of the intestine, but did not affect the peristalsis. Conclusion Bismuth sub salicylate has the anti-diarrhea effect, which can prevent diarrhea caused by various etiologies.