根据ｒａｐａｍｙｃｉｎ免疫抑制作用机理，应用含有ＲＢＰ基因的啤酒酵母基因工程菌ＲＳ１８８Ｎ及其变株ＲＳ１８８ＮΔｒｂｐ，建立了ｒａｐａｍｙｃｉｎ及其药效基团类似物的筛选模型，对３０００多个微生物次级代谢产物和一些植物提取物进行筛选，获得阳性结果活性物产生菌１株，编号ＳＩＡ９２６８，经菌种鉴定定名为吸水链霉菌东湖变种，其活性代谢产物经理化性质和波谱解析表明与ｒａｐａｍｙｃｉｎ为同一物质 According to the mechanism of rapamycin immunosuppression, a screening model of rapamycin and its pharmacophore analogues was constructed by using RSB8B gene of S. cerevisiae containing RBP gene and its mutant strain RS188NΔrbp. The secondary metabolites of rapamycin and some Plant extracts were screened to obtain a positive activity of the resulting activity of a strain of bacteria, number SIA9268, strain identification identified as Streptomyces hygroscopicus East Lake varieties, the active metabolites of the physical and spectral analysis showed that rapamycin with the same substance