【摘 要】
：
Speaking of asthma,one is immediately reminded of incessant coughing and wheezing,and the unsightly scene of phlegm-spitting.A wide range of remedies have been
【机 构】
：
The Model Animal Research Center, Nanjing University, Nanjing 210012, China
论文部分内容阅读
Speaking of asthma,one is immediately reminded of incessant coughing and wheezing,and the unsightly scene of phlegm-spitting.A wide range of remedies have been tried,ranging from ancient folklore belief of smelling honey to modem inhaling β2-adrenoceptor agonists,but none proves to have long-lasting effect for this common chronic pulmonary disease.As a Chinese proverb says,a good medicine always tastes bitter.Maybe the problem with those old remedies is that they are not bitter enough.Jokes aside,there may actually be some truth in this,as shown by a recent study from Stephen B.Liggett’s laboratory in the University of Maryland (Deshpande et al,2010).In a survey for G-protein coupled receptors (GPCR) in human airway smooth muscle (ASM),this group inadvertently identified several types of bitter taste receptors,which are members of the GPCR family.
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