目的　采用高效液相色谱法测定非那雄胺片的溶出度。方法　高效液相色谱法。色谱柱为LUNA 5 μmC18(2 ) (15 0×4 .6 0mm ,U .S .A) ,流动相为 2 .5mmol·L-1磷酸溶液 -乙腈 (1∶1) ,检测波长 2 2 0nm。结果　非那雄胺的最低检出量约为 2ng ;非那雄胺在 1.4～ 16 .8μg·ml-1(r =0 .9999)范围内 ,峰面积与其浓度呈良好线性关系 ,平均回收率为 99.6 1% ,RSD为 1.0 5 % (n=6 )。结论　分析速度快 ,简单 ,结果准确可靠 Objective To determine the dissolution of finasteride tablets by high performance liquid chromatography. Methods High performance liquid chromatography. The chromatographic column was LUNA 5 μm C18 (2) (150 × 4.600 mm, U.S.A). The mobile phase consisted of 2.5 mmol·L-1 phosphoric acid solution (1: 1) and the detection wavelength was 220 nm . Results The minimum detectable amount of finasteride was about 2 ng. The peak area of ​​finasteride was linearly correlated with its concentration in the range of 1.4-16.8 μg · ml-1 (r = 0.9999). The average recoveries 99.6 1% with a RSD of 1.0 5% (n = 6). Conclusion Analysis speed, simple, accurate and reliable results