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目的 为了解抗病毒 1号单味中草药对流感病毒B的抑制作用。方法 本研究采用细胞培养技术 ,以病毒唑为阳性对照药 ,观察抗病毒 1号对流感病毒的抑制作用。结果 抗病毒 1号半数中毒浓度(TC50 )为 60 53mg/ml ;治疗和预防给药方式均有抗流感病毒作用 ,其抗流感病毒B的半数有效浓度 (EC50 )分别为 8 88mg/ml和 9 2 1mg/ml ;治疗指数 (TI)分别为 6 81和 6 57。结论 抗病毒 1号对流感病毒B的抑制作用存在着明显的量效关系。
Objective To understand the inhibitory effect of antiviral No. 1 Chinese herbal medicine on influenza virus B. Methods In this study, cell culture technology was used and Ribavirin was used as a positive control drug to observe the inhibitory effect of antiviral No. 1 on influenza virus. Results The antiviral No. 1 poisoning concentration (TC50) was 60 53 mg/ml; both the therapeutic and preventive administration methods had anti-influenza virus effect, and the half effective concentration (EC50) of the anti-influenza virus B was 8 88 mg/ml and 9 respectively. 2 1mg/ml; treatment index (TI) were 6 81 and 6 57, respectively. Conclusion The inhibitory effect of antiviral No. 1 on influenza B has obvious dose-effect relationship.