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乙醇性脂肪肝过量摄取乙醇必然引起脂肪肝。这种脂肪肝主要是肝的中性脂肪的增加,其增加的来源是经口摄取的脂肪、末稍脂肪组织的脂肪和肝内合成的脂肪。考虑此种脂肪沉积的机制有四:①来自末稍脂肪组织的脂肪酸的动员、②肝内脂肪酸氧化的减少、③肝中脂肪酸产生及酯化的增进、④由肝分泌脂蛋白的抑制。乙醇的一次投与会引起肝脂肪量增加,尽管因实验条件不同,结果不一定一致。但一般是大量乙醇的一次投与将导致末稍脂肪组织的脂肪酸动员(通过儿茶酚胺),引起了肝脂肪量的增加,同时伴有高脂血症。对慢性脂肪摄取所引起的脂肪肝的发生,主要有
Alcoholic fatty liver excessive intake of ethanol will inevitably cause fatty liver. This fatty liver is predominantly an increase in the liver’s neutral fat, which is derived from orally ingested fat, fat in the distal adipose tissue, and fat synthesized in the liver. There are four mechanisms for considering this type of fat deposition: mobilization of fatty acids from terminal adipose tissue, reduction of intrahepatic fatty acid oxidation, enhancement of fatty acid production and esterification in the liver, and inhibition of hepatic secretion of lipoproteins. A single dose of ethanol can cause an increase in hepatic fat mass, although the results are not necessarily consistent due to different experimental conditions. However, in general, administration of a large amount of ethanol results in the mobilization of fatty acids (via catecholamines) in the terminal adipose tissue, causing an increase in hepatic fat mass accompanied by hyperlipidemia. The incidence of fatty liver caused by chronic fat intake, there are