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目的:观察巴马小型猪冠状动脉粥样硬化模型血清炎症因子变化,探讨炎症与冠状动脉粥样硬化发病的关系,同时观察冠脉的病理改变。方法:将巴马小型猪随机分配,对照组予基础饲料喂饲,模型组予高脂喂饲联合球囊拉伤。在多个时间点分别对两组行血管内超声、血清炎症因子检测和病理学分析。结果:第24周,冠状动脉血管内超声示对照组平均面积狭窄率为6.56%,模型组平均面积狭窄率为44.12%。第24周、28周、36周和48周,模型组hs-CRP、IL-6、VCAM-1、MCP-1和s P-selectin明显高于同期对照组,统计学差异显著。模型组24周可见冠状动脉内膜局部不规则增厚,增厚的内膜中存在泡沫细胞;48周可见冠状动脉内膜不规则增厚,粥样斑块形成,增厚的内膜中存在大量脂质、泡沫细胞、炎细胞及增生的纤维组织,动脉中膜受压变薄。结论:炎症反应在AS发生、发展和恶化中起重要作用,炎症加速了斑块的进展。
Objective: To observe the changes of serum inflammatory factors in coronary atherosclerosis model of Bama miniature pigs, to explore the relationship between inflammation and coronary atherosclerosis and to observe the pathological changes of coronary artery. Methods: Bama miniature pigs were randomly assigned. The control group was fed with basal diet. The model group was fed with high fat diet and balloon injury. At various time points, the two groups were subjected to intravascular ultrasound, serum inflammatory cytokines and pathological analysis. Results: In the 24th week, the average rate of stenosis in the control group was 6.56% and the average stenosis rate in the model group was 44.12%. The levels of hs-CRP, IL-6, VCAM-1, MCP-1 and s P-selectin in the model group were significantly higher than those in the control group at 24, 28, 36 and 48 weeks. In the model group, there was irregular thickening of the intima of the coronary artery at 24 weeks, and the presence of foam cells in the thickened intima; irregular thickening of the intima of coronary arteries, formation of atherosclerotic plaque and thickening of the intima existed at 48 weeks A large number of lipids, foam cells, inflammatory cells and hyperplastic fibrous tissue, arterial media pressure thinning. Conclusion: Inflammatory reaction plays an important role in the occurrence, development and progression of AS, and inflammation accelerates the development of plaque.