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在大鼠不同部位ｓｃ巯基化合物与含镉金属硫蛋白（ＣｄＭＴ），观察除去金属的金属硫蛋白（ＡｐｏＭＴ），Ｌ－半胱氨酸（Ｃｙｓ），还原型谷胱甘肽（ＧＳＨ）对大鼠ＣｄＭＴ损伤肾的保护作用。测定不同时相尿蛋白和尿碱性磷酸酶活性以及肾组织形态学结果表明，与单独给予ＣｄＭＴ比较，肾损伤作用明显减轻。ＡｐｏＭＴ，ＧＳＨ促使大鼠尿Ｃｄ排泄量显著增加，肾组织细胞中金属硫蛋白（ＭＴ）结合Ｃｄ和游离Ｃｄ含量明显降低，以ＧＳＨ尤为明显Ｃｙｓ能增加Ｃｄ在肾细胞内蓄积，提示在Ｃｄ中毒时，除ＭＴ对肾损伤有保护作用外，也有其它巯基化合物的参与，且作用机理不尽相同
In different parts of rat sc mercapto compounds and cadmium-containing metallothionein (CdMT), observed removal of metal metallothionein (ApoMT), L-cysteine (Cys), reduced glutathione Protective effect of CdMT on renal injury in rats. Determination of urinary protein and urinary alkaline phosphatase activity at different phases and morphological changes of kidney tissue showed that compared with CdMT alone, the renal injury was significantly reduced. ApoMT, GSH promoted the excretion of urinary Cd in rats significantly increased, the content of metallothionein (MT) bound Cd and free Cd in renal tissue cells decreased significantly. Especially GSH, Cys increased the accumulation of Cd in renal cells, suggesting that cadmium poisoning , In addition to the protective effect of MT on renal injury, there are other mercapto compounds involved, and the mechanism of action is not the same