热休克蛋白(hsp)有助于其他蛋白的装配、折叠和易位,并在保护细胞抵抗损伤和其他应激情况中起作用。另外,在感染和一些自身免疫病进展期间,hsp往往是免疫系统识别的主要抗原,从而有可能为开发免疫治疗剂提供新途径。本文介绍了hsp在健康和疾病时的作用,并讨论了hsp用于开发治疗剂/药物的正反面意见。 Heat shock proteins (hsp) contribute to the assembly, folding and translocation of other proteins and play a role in protecting cells against damage and other stress conditions. In addition, during the progression of infections and some autoimmune diseases, hsp is often the major antigen recognized by the immune system, potentially providing a new avenue for the development of immunotherapeutic agents. This article describes the role of hsp in health and disease and discusses the pros and cons of hsp for the development of therapeutics / drugs.