作者用1型宋内志贺菌O特异抗原基因转移到伤寒杆菌弱毒株Ty21a中,形成具有伤寒杆菌和宋内志贺菌两种O抗原的双价菌株5076-1C,用其制成冻干菌苗,给成人志愿者口服,观察反应及效果。共服3剂,每剂含1～8×10~9菌,每3～4天1次。服苗前先服2g碳酸氢钠,服苗后24～28小时,取大便标本作链霉素琼脂平皿分离菌落,用伤寒杆 The authors used Type 1 Shigella sonnei O-specific antigen gene transfer to Typhimurium attenuate Ty21a, the formation of two strains of Salmonella typhi and Shigella two O antigen bivalent strain 5076-1C, made of its lyophilized Bacterial vaccine, oral administration to adult volunteers, observe the reaction and effect. A total of 3 doses, each containing 1 ~ 8 × 10 ~ 9 bacteria, every 3 to 4 days 1 time. Clothes serving before serving 2g sodium bicarbonate, clothes after 24 to 28 hours, take stool specimens for streptomycin agar plate separation colonies, with typhoid rod