多系统器官衰竭(MSOF)是指严重感染、创伤、休克等疾病,发病24小时后,出现2个或2个以上重要系统器官同时或短时间内序贯发生功能衰竭的综合征。对原有慢性器官功能不全,或处于代偿状态,因感染、创伤、手术而恶化,致发生2个或2个以上系统器官衰竭者亦可诊断为MSOF。但慢性病终末期的器官衰竭或发病后24小时内死亡者,不属于MSOF。其发病机理复杂,预防及治疗困难,是目前急诊医学的重要课题之一。我院自1993年1月至1995年4月共发生MSOF的成年病人144例,报告如下: MSOF refers to severe infection, trauma, shock and other diseases. After 24 hours of onset, two or more major systemic organs appear syndromes of sequential or simultaneous failure. The original chronic organ dysfunction, or in compensation, due to infection, trauma, surgery and deterioration, resulting in two or more of the system organ failure can also be diagnosed as MSOF. But the end of chronic disease organ failure or within 24 hours after onset of death, does not belong to the MSOF. Its pathogenesis is complex, prevention and treatment difficulties, is currently one of the important topics in emergency medicine. Our hospital from January 1993 to April 1995 occurred in MSOF 144 cases of adult patients, the report is as follows: