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将药物静脉注射到动物体内 ,以观察188Re -HEDP注射液在动物体内代谢动力学的特征。结果表明 ,滞留在荷瘤大鼠患骨中的放射性比在正常骨中的多 (P <0 .0 5 ) ;小鼠 72h内排泄放射性累积百分率约为 82 %(其中尿液排泄为 80 %) ;体外血浆蛋白结合率为 86 .4 %± 0 .30 %。说明该药物是亲骨药物 ,血清除快符合药物代谢动力学二室模型 ,大部分的药物以原形从肾排出。
The drug was intravenously injected into animals to observe the pharmacokinetics of 188Re-HEDP injection in animals. The results showed that the radioactivity retention in the bone of tumor-bearing rats was more than that in normal bone (P <0.05); the percentage of radioactivity in mice excreted within 72 hours was about 82% (urine excretion was 80% ). The in vitro plasma protein binding rate was 86.4% ± 0.30%. Indicating that the drug is a pro-bone drug, serum fasting in line with pharmacokinetic two-compartment model, the majority of drugs in the prototype from the kidneys.