论文部分内容阅读
目的分析早产儿出血的危险因素。方法通过收集整理2014年1月至2016年1月重庆医科大学附属儿童医院615例住院早产儿的临床资料(基本资料、围产因素、出血表现等)和相关实验室检查(凝血5项、血小板计数、白细胞计数),根据临床诊断是否有出血分为出血组和未出血组,先对两组患儿的临床资料及相关实验室检查进行单因素分析,然后对经过单因素分析有显著意义的自变量进行多因素Logistic回归分析。结果单因素分析发现两组患儿之间的胎龄、是否有窒息复苏史、白细胞计数、血小板计数和凝血5项中的凝血酶原时间和纤维蛋白原的差异有统计学意义(P<0.05,P<0.01)。多因素Logistics回归分析结果显示两组间胎龄、是否有窒息复苏史、血小板计数、白细胞、纤维蛋白原值差异有统计学意义(P<0.05),胎龄、血小板计数和纤维蛋白原升高是保护因素,窒息复苏史、白细胞高是危险因素。结论早产儿胎龄低、有窒息复苏史、白细胞高、血小板计数和纤维蛋白原低均要警惕有出血的风险。
Objective To analyze the risk factors of bleeding in premature infants. Methods The clinical data (basic data, perinatal factors, bleeding manifestations, etc.) of 615 preterm infants admitted to Chongqing Children’s Hospital of Chongqing Medical University from January 2014 to January 2016 were collected and analyzed, and related laboratory tests (5 items of blood coagulation, Count, white blood cell count), according to whether the clinical diagnosis of hemorrhage was divided into hemorrhage group and non-hemorrhage group, first of the two groups of children with clinical data and related laboratory tests univariate analysis, and after univariate analysis was significant Multivariate logistic regression analysis of independent variables. Results Univariate analysis showed that gestational age, history of resuscitation with apnea, white blood cell count, thromboplastin time, and prothrombin time in fibrinogen were significantly different between the two groups (P <0.05 , P <0.01). Multi-factor Logistic regression analysis showed that gestational age, history of apnea and resuscitation, platelet count, white blood cell count and fibrinogen value had statistical significance (P <0.05), gestational age, platelet count and fibrinogen Is a protective factor, the history of apnea recovery, high white blood cell is a risk factor. Conclusions Premature babies have low gestational age with a history of asphyxia, high white blood cell count, low platelet count and low fibrinogen, all at risk of bleeding.