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采用微盘比色法，通过对一氧化氮代谢产物亚硝酸盐的测定，对３２例尸体肾移植患者术前及术后３个月的血浆一氧化氮（ＮＯ）水平的变化进行了动态观察；同时，对血浆内皮素（ＥＴ）、环孢素Ａ（ＣｓＡ）、肌酐（Ｃｒ）、尿素氮（ＢＵＮ）及血压亦做了监测。结果：肾移植前血浆ＮＯ浓度为２４．０１±１．１５μｍｏｌ／Ｌ，显著高于术后３个月内各阶段（Ｐ＜０．０１），血浆ＥＴ、ＢＵＮ和血压亦呈相似的变化趋势，并与ＮＯ呈显著相关。作者认为肾移植后ＮＯ浓度测定不仅有助于了解肾移植后肾损伤的机理，亦可作为一项肾功能监测的参考指标。
The changes of plasma nitric oxide (NO) level in 32 cases of cadaveric renal allografts before and 3 months after operation were observed by microdisk colorimetry and nitrite determination of nitric oxide metabolites. At the same time, plasma endothelin (ET), cyclosporin A (CsA), creatinine (Cr), blood urea nitrogen (BUN) and blood pressure were also monitored. Results: The plasma concentration of NO before kidney transplantation was 24.01 ± 1.15μmol / L, which was significantly higher than that in the 3 months after operation (P <0.01). The plasma ET, BUN and blood pressure also showed similar trends , And was significantly correlated with NO. The authors believe that the determination of NO concentration after kidney transplantation not only helps to understand the mechanism of kidney injury after kidney transplantation, but also as a reference indicator of renal function monitoring.