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胸腺基质淋巴细胞生成素（TSLP）是一类白细胞介素7（IL－7）样细胞因子，在变态反应中具有重要作用。近些年，学者们逐渐将目光聚焦在TSLP与风湿性疾病的关联。在类风湿关节炎、系统性硬化症中TSLP表达显著增高，与疾病进程显著相关；而在原发性干燥综合征中TSLP表达降低，与相关临床指标呈负相关。 TSLP在多种风湿性疾病的病理机制中扮演着不同角色，有望成为崭新的干预靶点。“,”Thymic stromal lymphopoietin (TSLP) is an interleukin-7(IL-7)-related cytokine that has been studied abundantly in allergic reaction .Recently there are more researches on TSLP in various rheumatic disorders.TSLP is significantly overexpressed in rheumatoid arthritis ( RA) and systemic scleroderma ( SSc) which is correlated with disease progress;whereas TSLP is underexpressed in primary Sjogren syndrome ( pSS) ,and showed negative correlation with the related clinical index .TSLP plays different roles in multiple rheumatoid diseases and is become to become the potential therapeutic target .