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目的 :探讨透明质酸 (HA)、Ⅳ型胶原 (Ⅳ -C)、层粘连蛋白 (LN)在淋巴瘤病变中的变化。方法 :采用放射免疫法测定 6 3例淋巴瘤患者与 2 8例健康人血清HA ,Ⅳ -C和LN水平。结果 :淋巴瘤患者Ⅳ -C和LN水平与正常组相比较有显著性差异 (P <0 .0 0 1) ;NHL患者血清HA水平与正常对照组相比较有显著性差异 (P<0 .0 0 1) ,HD患者血清HA水平与正常对照组比较无显著性差异 (P >0 .0 5 ) ;淋巴瘤患者治疗缓解后HA ,Ⅳ-C和LN水平均有减低 ,复发后均有升高。结论 :血清HA ,Ⅳ -C和LN水平的变化可作为临床判断淋巴瘤患者病情缓解、复发及预后的参考指标。
Objective: To investigate the changes of hyaluronic acid (HA), type Ⅳ collagen (Ⅳ -C) and laminin (LN) in lymphomas. Methods: Serum levels of HA, Ⅳ -C and LN in 63 patients with lymphoma and 28 healthy controls were determined by radioimmunoassay. Results: The levels of C-C and LN in patients with lymphoma were significantly different from those in normal controls (P <0.01). The levels of serum HA in patients with NHL were significantly lower than those in controls (P <0.01). There was no significant difference in serum HA levels between patients with HD and normal controls (P> 0.05). The levels of HA, IV-C and LN in patients with lymphomas after treatment were significantly reduced Rise. Conclusion: The changes of serum HA, Ⅳ -C and LN levels can be used as a reference index for judging the prognosis, remission and prognosis of patients with lymphoma clinically.