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目的 :探讨山梨醇脱氢酶 (SDH)活性与SOD活性及MDA含量在急性肝损伤中的相互关系。方法 :采用急性CCl4 肝损伤模型 ,观察大白鼠肝匀浆及血浆中MDA含量 ,SDH、SOD活性变化。结果 :肝损伤组与对照组比较 ,前者血及肝匀浆中SDH活性增高 ,SOD活性明显降低 ,MDA含量增加 ,且SDH活性与MDA含量呈正相关 ,与SOD活性呈负相关。结论 :此三项指标能有效地反映肝损伤后体内过氧化系统的异常程度 ,可用做肝病的诊断及愈后观察的一种辅助性指标
Objective: To investigate the relationship between sorbitol dehydrogenase (SDH) activity and SOD activity and MDA content in acute liver injury. Methods: Acute CCl4 liver injury model was used to observe the content of MDA and the activity of SDH and SOD in the liver homogenates and plasma of rats. Results: Compared with the control group, the activity of SDH in the blood and liver homogenate of the liver injury group was significantly increased, the activity of SOD was significantly decreased, the content of MDA was increased, and the activity of SDH was positively correlated with the content of MDA and negatively correlated with the activity of SOD. Conclusion: These three indicators can effectively reflect the degree of anoxia in vivo after liver injury, and can be used as a supplementary indicator for the diagnosis and prognosis of liver disease