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20(S)-原人参二醇奥克梯隆型差向异构体为20(S)-原人参二醇的主要代谢产物,前期研究发现,该差向异构体在药效学和药动学方面均有一定的立体选择性。该文建立了HPLC-MS/MS测定大鼠尿液、粪便和胆汁中的24R-差向异构体和24S-差向异构体,考察口服灌胃给予大鼠24R-差向异构体或24S-差向异构体后,在尿液、粪便和胆汁中的排泄情况。结果显示,24R-差向异构体和24S-差向异构体在口服给药后48 h内粪便排泄累积量分别为给药剂量的17.69%,17.09%,基本不经尿排泄。口服给药后48 h内,24R-差向异构体和24S-差向异构体胆汁排泄累积量分别为给药剂量的8.01%,1.47%,前者是后者的5.4倍,具有明显的立体选择性。
20 (S) - protopanaxadiol octocopherol epimer is 20 (S) - protopanaxadiol the main metabolite, the previous study found that the epimers in pharmacodynamics and medicine Kinematics has a certain degree of stereoscopic selectivity. In this study, 24R-epimer and 24S-epimer in urine, feces and bile were determined by HPLC-MS / MS. The rats were orally administered with 24R-epimer Or 24S-epimer, in urine, feces and bile excretion. The results showed that the excretion excretion of 24R-epimer and 24S-epimer in 48 hours after oral administration were 17.69% and 17.09% of the administered dose, respectively, with no excretion of urine. Within 48 h after oral administration, the cumulative amounts of 24R-epimer and 24S-epimer bile excreted were 8.01% and 1.47% of the dose, respectively. The former was 5.4 times of the latter with significant Stereoselective.