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研究证明Dopexamine兴奋β_2和多巴胺受体,但不影响β_1和α受体;它有显著血管扩张和正性肌力作用,使心功能改善。作者研究了多培沙明(Dopexamine)对心衰患者的中枢和肾血流动力学效应。 9例慢性充血性心力衰竭患者,心功能Ⅲ～Ⅳ级,病程21±19个月。维持洋地黄治疗,静脉滴注Dopexamine每分钟1.0μg/kg,每15分钟增加本品每分钟1.0μg/kg,直至最大耐受量。每分钟滴注1μg/kg时,血流动力学无明显变化。每分钟2μg/kg时,心率由88±20增快至95±23bpm,最大耐受量每分钟7.2±4.0μg/kg时心率进一步增快至104±
Studies have shown that Dopexamine is excited β_2 and dopamine receptors, but does not affect the β_1 and α receptors; it has significant vasodilatation and positive inotropic effect, so that heart function improved. The authors studied the central and renal hemodynamic effects of Dopexamine in patients with heart failure. Nine patients with chronic congestive heart failure, cardiac function Ⅲ ~ Ⅳ grade, duration of 21 ± 19 months. Maintain digitalis treatment, intravenous infusion of Dopexamine 1.0μg / kg per minute, every 15 minutes to increase the product 1.0μg / kg per minute, until the maximum tolerated. There was no significant change in hemodynamics at 1 μg / kg per minute. At 2 μg / kg, the heart rate increased from 88 ± 20 to 95 ± 23 bpm and the maximum tolerated heart rate further increased to 104 ± 7.2 ± 4.0 μg / kg