盐酸曲唑酮(trazodone hydrochloride)具有三唑吡碇(triazolopyridine)的特征,与三(四)环类抗忧郁药不同,具有选择性阻碍5-羟色胺再吸收作用,对用地抗忧郁药筛选的利血平有拮抗作用,并可增强安非他明的作用。在药理作用上具有较强的α受体阻滞作用,可显示与该作用强度密切相关的镇静作用和降血压作用。此外,几乎无毒扁豆碱中毒致死抑制作用(动物),对循环系统作用弱且几乎无心脏毒性。第Ⅰ期试验表明,健康成人给药3～4小时后血浆中浓度达峰值,6～7小时半减期缩短。反复给药血浆浓度从给药第二天起达恒 Trazodone hydrochloride, which has the characteristics of triazolopyridine, is different from the three (four) -cyclic anti-depressant drug and has the effect of selectively blocking the reabsorption of serotonin. The trazodone hydrochloride Blood levels have antagonistic effects, and enhance the role of amphetamine. Pharmacological role in the strong α-blocker effect, can be shown to be closely related to the role of sedation and antihypertensive effect. In addition, the almost lethal effect of non-toxic physostigmine (animal) is weak on the circulatory system with little cardiotoxicity. The first phase of the trial showed that plasma concentrations reached the peak in healthy adults after 3 to 4 hours of administration, and their half-term reductions of 6 to 7 hours were shortened. Repeatedly administered plasma concentration reached constant from the next day of administration