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目的：观察氯雷他定与阿司咪唑治疗常年变应性鼻炎疗效的对比。方法：将患有常年变应性鼻炎２１８例（男性９７例，女性１２１例，年龄３７±ｓ２２ａ），随机分为氯雷他定组１６６例与阿司咪唑组１１２例，２组的性别、平均年龄及病情具可比性。氯雷他定组与阿司咪唑组分别口服氯雷他定与阿司咪唑１０ｍｇ／ｄ±１２ｄ，于ｄ１，ｄ１３及停药后ｄ７复诊。结果：氯雷他定组及阿司咪唑组有效率分别为９１．５％及７８．６％，Ｒｉｄｉｔ分析Ｐ＜０．０５。结论：对治疗常年变应性鼻炎，氯雷他定比阿司咪唑疗效显著。
Objective: To observe the efficacy of loratadine and astemizole in the treatment of perennial allergic rhinitis. Methods: 218 cases of perennial allergic rhinitis (97 males and 121 females, age 37 ± s22a) were randomly divided into loratadine group 166 cases and astemizole group 112 cases. The gender, The average age and condition are comparable. Loratadine group and astemizole group were treated with loratadine and astemizole 10mg / d ± 12d, d1, d13 and d7 referral after stopping. Results: The effective rates of loratadine group and astemizole group were 91.5% and 78.6% respectively, Ridit analysis P <0.05. Conclusion: The efficacy of loratadine versus astemizole is significant for the treatment of perennial allergic rhinitis.