真核细胞增殖、生长及凋亡、生存受到细胞内一系列蛋白质的调控。因此,细胞内蛋白的有序降解对细胞功能、生存极为重要。80%以上的细胞内蛋白质,包括调节细胞周期的多种蛋白的降解均由泛素-蛋白酶体完成。因此,泛素-蛋白酶体通路是细胞内蛋白质降解的主要通路,蛋白酶体自然成为 Eukaryotic cell proliferation, growth and apoptosis, survival of a series of proteins within the cell regulation. Therefore, the orderly degradation of intracellular proteins plays an important role in cell function and survival. More than 80% of intracellular proteins, including the regulation of cell cycle degradation of a variety of proteins by the ubiquitin - proteasome. Therefore, the ubiquitin-proteasome pathway is the major pathway for protein degradation in the cell and the proteasome naturally becomes