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目的：检测新生儿期血清免疫抑制酸性蛋白（ＩＡＰ）水平，探讨其在新生儿感染时的临床意义；方法：采用单向免疫扩散法，测定了４０份正常新生儿和８７份感染与非感染新生患儿的血清ＩＡＰ水平。结果：正常新生儿血清ＩＡＰ值低于１８５ｍｇ／Ｌ，感染新生儿血清ＩＡＰ值明显高于正常新生儿及非感染新生儿（Ｐ＜０００１），而严重感染又明显高于一般感染（Ｐ＜０００５）。其中３５例新生患儿血清还同时检测Ｃ反应蛋白（ＣＲＰ）。结果表明，新生儿感染时血清ＩＡＰ异常增高的检出率大于ＣＲＰ的阳性率（Ｐ＜００１）。结论：检测血清ＩＡＰ水平有助于新生儿感染的临床诊断及疾病严重程度的判断，可以作为新生儿感染的辅助诊断方法之一。
Objective: To detect the level of serum immunosuppressive acid protein (IAP) in neonatal period and to explore its clinical significance in neonatal infection.Methods: One-way immunodiffusion method was used to detect 40 normal neonates and 87 infected and non-infected Serum IAP levels in newborn infants. Results: The serum IAP of normal neonates was lower than 185mg / L, the serum IAP of newborn infants was significantly higher than that of normal newborns and noninfected infants (P <0001), while the severe infection was significantly higher than that of general infection <0005). 35 cases of neonatal serum also detect C-reactive protein (CRP). The results showed that the detection rate of abnormal serum IAP in neonates was higher than that of CRP (P <001). Conclusion: The detection of serum IAP level is helpful to the clinical diagnosis and severity judgment of neonatal infection, and it can be used as one of the diagnostic methods for neonatal infection.