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目的探讨血清抗甲状腺球蛋白抗体(Tg Ab)和抗甲状腺过氧化物酶抗体(Tpo Ab)水平检测在甲状腺疾病诊断中的临床价值。方法选择在我院治疗的266例甲状腺疾病患者作为研究对象,按照疾病诊断结果将其分为A组与B组,A组为非自身免疫性甲状腺疾病(甲亢、甲减、甲状腺肿瘤等,合计156例),B组患者为自身免疫性甲状腺疾病(Graves,桥本病,合计110例),另选择60例体检健康者作为对照组。比较各组间Tg Ab和Tpo Ab水平含量。结果检测后B组Tg Ab、Tpo Ab测定结果、抗体阳性率均高于A组,差异有统计学意义(P<0.05);对照组Tg Ab、Tpo Ab与甲状腺腺瘤相比,差异无统计学意义(P>0.05);而甲减、甲亢、分化型甲状腺癌、Graves病、桥本病患者的Tg Ab、Tpo Ab水平均高于对照组,差异有统计学意义(P<0.05)。结论甲状腺疾病采用Tg Ab、Tpo Ab指标检测效果满意,临床应用价值高。
Objective To investigate the clinical value of serum anti-thyroglobulin antibody (Tg Ab) and anti-thyroid peroxidase antibody (Tpo Ab) in the diagnosis of thyroid diseases. Methods A total of 266 thyroid disease patients treated in our hospital were selected as the research objects. According to the results of the disease diagnosis, they were divided into group A and group B. Group A was non-autoimmune thyroid disease (hyperthyroidism, hypothyroidism, thyroid tumor, etc.) 156 cases), group B was autoimmune thyroid disease (Graves, Hashimoto’s disease, a total of 110 cases), and the other 60 cases were selected as the control group. The levels of Tg Ab and Tpo Ab in each group were compared. Results The positive rate of Tg Ab and Tpo Ab in group B was significantly higher than that in group A (P <0.05), while there was no significant difference between Tg Ab and Tpo Ab in thyroid adenoma (P> 0.05). The levels of Tg Ab and Tpo Ab in patients with hypothyroidism, hyperthyroidism, differentiated thyroid cancer, Graves disease and Hashimoto were higher than those in the control group (P <0.05). Conclusion Thyroid disease using Tg Ab, Tpo Ab index detection results are satisfactory, clinical application of high value.