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肝内胆汁郁积常由肝炎病毒引起。已知急性肝炎伴肝内胆汁郁积多呈局限性,预后较好;而对慢性肝炎伴胆汁郁积的经过和预后尚了解不多。近四年来,我们共确诊39例慢性肝炎伴胆汁郁积,发现其临床经过和预后不尽相同,主要与肝内原来病变情况有关。 39例的诊断全部符合以下条件:(1)肝病病程大于6个月;(2)实验室检查显示为阻塞性黄疸;(3)经皮肝穿刺造影(PTC)、内窥镜下逆行性胰胆管造影(ERCP),B型超声和/或手术排除胆道机械性梗阻;(4)病史、生化检查可除外药物、毒素、妊娠、酒精引起的胆汁郁积;(5)肝活检符合肝内胆汁郁积。
Intrahepatic cholestasis often caused by the hepatitis virus. It is known acute liver disease with intrahepatic cholestasis more than the limitations, the prognosis is good; and chronic hepatitis with cholestasis and prognosis is still not much. In the past four years, we have diagnosed a total of 39 cases of chronic hepatitis with cholestasis and found that the clinical course and prognosis are different, mainly related to the original intrahepatic lesions. The diagnosis of 39 cases all meet the following conditions: (1) the course of liver disease is more than 6 months; (2) laboratory examination showed obstructive jaundice; (3) percutaneous transhepatic puncture (PTC) Cholangiography (ERCP), B-mode ultrasound and / or surgical exclusion of biliary mechanical obstruction; (4) history, biochemical tests can be excluded drugs, toxins, pregnancy, alcohol-induced cholestasis; (5) liver biopsy consistent with intrahepatic cholestasis .