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绒毛膜促性腺激素及其类似蛋白的生成与分布:〔丸尾猛:第34回日本产科妇人科学会总会学术讲演会抄录集:29,1982(日本)〕由滋养层产生分泌的hCG是具有黄体化的生物学作用的糖蛋白激素,曾认为是妊娠及滋养层疾病特有的激素。但近年来由于引进放射免疫法及免疫组织学,在各种肿瘤组织中也发现了有免疫活性的hCG,并且在正常男子、非孕妇女的血、尿中见到类似蛋白的存在,而对非滋养层的类似hCG的产生问题引起了关注。另一方面分子生物学的研究加速了关于滋养层产生hCG机制的研究进展,逐渐阐明其亚单位生成的遗传信息。滋养层的hCG生成与分泌:hCG于α及β两种亚单位构成,生成过程上各自的遗传信息转录成mRNA的硷基排列,在核蛋白体上接受翻译,先
Generation and distribution of human chorionic gonadotropin and its analogous proteins: [Maruo Maruko: The 34th Japan Society of Obstetrics and Gynecology Women’s Science Academic Conference Transcript: 29,1982 (Japan)] The hCG produced by the trophoblast is Luteinizing biological role of the glycoprotein hormones, once thought to be unique to pregnancy and trophoblast hormones. However, due to the introduction of radioimmunoassay and immunohistology in recent years, immunocompetent hCG has also been found in various tumor tissues, and similar proteins are found in the blood and urine of normal men and non-pregnant women. Non-trophoblast-like hCG generation problems caused concern. On the other hand, research in molecular biology has accelerated the research on the mechanism of hCG production by trophoblast, and gradually clarified the genetic information generated by its subunits. Trophoblast hCG generation and secretion: hCG in α and β two subunits, the formation of genetic information on their respective transcribed into the mRNA base sequence, the ribosome accept translation, the first